Guided Bone Regeneration through Ossification of OSSIX® Plus Collagen Membrane Cross-linked with Sugar
A 2008 J Periodontol article highlights the Ossification properties of OSSIX® Plus, a barrier membrane used for guided bone regeneration (GBR). The purpose of this case series was to histologically evaluate GLYMATRIX™ technology in GBR procedures in humans.
GLYMATRIX™ technology is a patented process which allows for exceptional biocompatibility created using a natural sugar cross-linking.
The photograph and radiograph of the (A) bony defect between implants in tooth #13 position. (B) OSSIX® Plus placed over the defect to maintain space. Immediate postoperative radiograph (inset: upper right). (C) Digital radiograph after 29 weeks clearly showing a radiopaque zone over the augmented area (arrows), with a radiolucent zone underneath. (D) Clinical photograph at 29 weeks showing the tissue over the augmented zone from which the biopsy was taken (between the two arrows).
In the above photo you can see the bony defect between implants. OSSIX® Plus was placed over the defect and tacked for stabilization. No particulate has been used, just the membrane. In the radiograph image it becomes apparent that there has been an increase in bone volume. At 29 weeks the membrane is still visible and where it has been in contact with autogenous bone, it has ossified. The long-lasting barrier function of this membrane also contributes to additional tissue growth.
Membrane ossification at 24 weeks in H&E (A) and MT-stained (B) sections. Note the continuity and integrity of the membrane and ossified area and the vital osteocytes within the glycated collagen. Non-vital autogenous bone fragments are in close contact with the membrane embedded in fragments are in close contact with the membrane embedded in fibrous connective tissue. (Original magnification x 10).
The conclusion of this study showed that OSSIX® Plus (GLYMATRIX™ technology) maintained its barrier effect in ﬁve of seven cases for 25 weeks and induced dense new bone along its interface with underlying tissues.
J Periodontol 2008;79:1101-1107.