September 08, 2017


Biotex®

Biotex® Suture is a non-absorbable monofilament made of 100% medical grade polytetrafluotoethylene (PTFE). Many types of sutures are available in the market, these materials are classified by diameter, resorbability, and weather they are monofilament or polyfilament. Monofilament sutures such a Biotex® are ideal for dental bone grafting, implant procedures, periodontal surgery that requires elimination of bacterial wicking while maintaining flexibility and ultimate patient comfort.  
  

Traditionally, silk has been the mostly used suture material for dental and several other surgical procedures []. Even though silk is inexpensive and easy to handle as compared to other nonabsorbable suture materials []; the authors believe that it should not be considered as a “material of choice” for oral surgical interventions. Studies on oral tissue reactions to sutures have revealed constant inflammatory reactions, which are most prominent with silk and cotton and minimal with others including nylon, polyester, ePTFE, polyglecaprone 25 and PGA []. A histological study [] compared the oral tissue reactions to various suture materials. The results showed the presence of a large number of neutrophilic polymorphonuclear leukocytes in the premises of silk sutures which were less intense in oral tissues farther from silk sutures []. Another finding was that fibroblasts and new capillaries formed at a slower pace in the oral tissues in the vicinity of silk sutures compared to tissues farther from the silk sutures. This may be a justification for the delayed healing and severe tissue reactions associated with silk sutures.

                                                                                                               

Another factor that may instigate tissue reactions is the capability of bacteria to adhere to various suture materials. In their in vitro study, Katz et al. [] investigated the capability of bacteria to adhere to various types of sutures to cause tissue reactions. The results showed that bacterial adherence to braided silk sutures was five- to eightfolds higher as compared to nylon to which the least numbers of bacteria adhered []. In another study [], colonization on various intraoral suture materials from patients microbial having undergone dentoalveolar surgery was investigated. The results showed a larger numbers of bacteria on silk as compared to polyglecaprone 25 []. In an experimental study, Leknes et al. [] investigated the inflammatory responses in oral tissues sutured with silk and ePTFE by recording the presence or absence of bacterial plaque along the suture track. The results showed that bacterial plaque was present in 10 out of the 11 silk and 4 out of the 11 ePTFE suture channels []. These studies may act as possible explanations to the minimum tissue reactions evoked in nylon and polyglecaprone 25 as compared to braided silk sutures. Thus, the different rates of bacterial adherence to various suture materials support the hypothesis that bacterial adherence to sutures plays a significant role in the induction of tissue reactions. Since sutures are immediately contaminated as soon as they contact the oral cavity, it is recommended that sutures should be opened just before being passed through the gingival tissues in order to minimize complications such as stitch abscesses [].

It is still evident that various suture materials used in oral surgical interventions present varying degrees of tissue reactions depending on several factors including surface properties and bacterial adherence properties. The present information emphasizes on the need for careful suture selection of suturing materials for oral surgical interventions.

  

                The following case shows the advanced healing process where Biotex® was used.                                                                                                            

   

                       The table below shows the histological findings in different types of suture.                                                                                                                                                                                                                                                                                               

  

 

  3. Lilly GE, Armstrong JH, Salem JE, Cutcher JL. Reaction of oral tissues to suture materials. Part II. Oral Surgery, Oral Medicine, Oral Pathology. 1968;26(4):592–599.  [PubMed] 5. Lilly GE, Salem JE, Armstrong JH, Cutcher JL. Reaction of oral tissues to suture materials. Part III. Oral Surgery, Oral Medicine, Oral Pathology. 1969;28(3):432–438.  [PubMed] 7. Yilmaz N, Inal S, Muğlali M, Güvenç T, Baş B. Effects of polyglecaprone 25, silk and catgut suture materials on oral mucosa wound healing in diabetic rats: an evaluation of nitric oxide dynamics. Medicina Oral, Patologia Oral y Cirugia Bucal. 2010;15(3):e526–e530.  [PubMed] 10. Leknes KN, Røynstrand IT, Selvig KA. Human gingival tissue reactions to silk and expanded polytetrafluoroethylene sutures. Journal of Periodontology. 2005;76(1):34–42.  [PubMed] 15. Abi Rached RS, de Toledo BE, Okamoto T, et al. Reaction of the human gingival tissue to different suture materials used in periodontal surgery. Brazilian Dental Journal. 1992;2(2):103–113.  [PubMed] 19. Lilly GE. Reaction of oral tissues to suture materials. Oral Surgery, Oral Medicine, Oral Pathology. 1968;26(1):128–133.  [PubMed] 21. Macht SD, Krizek TJ. Sutures and suturing: current concepts. Journal of Oral Surgery. 1978;36(9):710–712.  [PubMed] 22. Ananthakrishnan N, Rao RS, Shivam S. Bacterial adherence to cotton and silk sutures. The National medical journal of India. 1992;5(5):217–218.  [PubMed] 23. Katz S, Izhar M, Mirelman D. Bacterial adherence to surgical sutures. A possible factor in suture induced infection. Annals of Surgery. 1981;194(1):35–41. [PMC free article]  [PubMed

 

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June 29, 2017


Winner of 2017 Dental Excellence Award: OSSIX® VOLUMAX

OSSIX® VOLUMAX our latest regenerative material released for use to Canadian clinicians at the start of 2017 has won 2017 Dental Excellence Award

OSSIX® VOLUMAX is a thick, ribose cross-linked collagen scaffold which restores lost volume in Guided Bone Regeneration (GBR) and Guided Tissue Regeneration (GTR) procedures. It is developed using the patented GLYMATRIX™ technology unique to the OSSIX® line of regenerative materials which allows for high biocompatibility as the material has the ability to ossify. 

This unique material was first introduced and launched in North America at the 102nd American Academy of Periodontology Meeting held in San Diego, CA, Sept/16.  It was first presented in Canada at an educational evening held in Nov/16 in Montreal, QC, by Dr. Barry Levin (staff at the University of Pennsylvania-Periodontal & Dental Implant Surgery Dept since 1996).  OSSIX® VOLUMAX was presented in Toronto, ON, for an educational evening by Dr. Yuval Zubery (global presenter on periodontics and author of over 35 publications) on Wednesday, Jan 18th/17  and again on Thursday, Jan 19th/17 due to demand.  

Application* of OSSIX® VOLUMAX can include:

  • To correct dehiscence-type defects with implants
  • For extra volume in lateral and vertical bone augmentation procedures
  • In one-stage implant procedures to ensure sufficient buccal bone
  • To augment soft tissue implants, pontic sites, masking of implants, etc.

For more information or to order:

HesiraMed.com
info@hesiramed.com

844-HESIRA-1

 

  

@HesiraMed

 

* Please read IFU before use and for any additional info on indications, contraindications, warnings, and precautions. 

January 04, 2017


OSSIX® VOLUMAX now available for use within Canada

Hesira Med is excited to start the new year off by announcing that OSSIX® VOLUMAX has received licensing from Health Canada and is now available for use by Canadian clinicians. This is the newest product to be added to the OSSIX® line of dental regenerative materials.

OSSIX® VOLUMAX is a new and unique 3L (three layer) scaffold that was developed using patented GLYMATRIX™ technology which allows for exceptional biocompatibility by using ribose (a natural sugar) cross-link. The multi-layer scaffold allows for osteoblast penetration and studies have demonstrated that it will mineralize progressing into ossification (cell mediated remolding into bone).  Since the thickness of the scaffold is 1-2mm, an ideal indication for OSSIX® VOLUMAX is to place it on the buccal wall in order to achieve additional bone volume. 

There are dozens of on-going OSSIX® VOLUMAX research studies. At the 102nd Annual Meeting of the American Association of Periodontology and the 25th Scientific Meeting of the European Association for Osseointegration data was presented demonstrating that both OSSIX® PLUS the resorbable collagen membrane and OSSIX® VOLUMAX outperformed the controlled cases.  OSSIX® VOLUMAX had higher instances of ossification at 24 weeks than OSSIX® PLUS.

Reference: Alveolar Ridge Augmentation and Ossification of Thick vs. Thin Sugar Cross-Linked Collagen Membranes in a Canine L-shape Defect Model. 

 

These pictures taken from the study show the movement of new bone (arrows) into the OSSIX® VOLUMAX and by 24 weeks the ossification of the OSSIX® VOLUMAX is almost complete. The study concludes that this new scaffold has the potential to augment thin tissue around implants, aesthetic deficiencies, and correct residual dehiscence after regenerative procedures. It can be used in direct contact with native bone or with bone grafting materials such as our competitively priced OSSIX™ GRAFT an allograft bone particulate. 

For more information or to order online to go:

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November 23, 2016

Education Events ›  


Dr. Barry Levin presents Guided Bone Regeneration with Confidence

Recently we were able to host clinicians at an event held in downtown Montreal, QC. The event featured a presentation by the accomplished speaker Dr. Barry P. Levin.

Dr. Barry Levin is a diplomate of the American Board of Periodontology. He has been teaching the periodontal and implant surgery in the graduate periodontal program at the University of Pennsylvania since 1996. He has authored or co-authored over 20 articles in peer-reviewed journals.  

Dr. Levin presented on Guided Bone Regeneration with Confidence. His cases included the OSSIX® PLUS and how the resorbable membrane can yield excellent bone quality even if it is left exposed. He noted the ossification of the OSSIX® PLUS membrane and described the unique patented GLYMATRIX® technology which uses ribose sugar as a cross-linking agent.  Since a chemical such as an aldehyde is NOT used, studies show that OSSIX® does not cause a foreign body reaction like other cross-linked membranes (Rothamel et al. Biodegradation of collagen membranes, Clin. Oral Impl. Res. I6, 2005 / 369-378).  

OSSIX® VOLUMAX was launched at the 2016 American Academy of Periodontology meeting, thus, Dr. Levin has had the opportunity to work with this new unique 3D scaffold. He has used it around the collar of implants in order to achieve additional bone volume. OSSIX® VOLUMAX is now Health Canada approved and we will have it available to Canadian clinicians within a few weeks, stay tuned! 

 

OSSIX® line of regenerative products can be ordered online HesiraMed.com

@Hesira_Med

  

July 29, 2016

Launch ›   New products ›  


Preparing for end of summer OSSIX GRAFT launch

It has been a hot summer! While it may have become that much harder to work when the sun is shining so invitingly, the Hesira Med team is keeping their noses to the grindstone. We are passionate about providing Canadians with cutting edge products so that you can smile widely for those fun summer pics.  Don't avoid the camera on your summer vacation, take care of your smile. Dental implants help to provide you with the confidence you need to enjoy yourself. Have an adventure this summer and don't worry, our passion is to help you smile by bringing you new innovative products.  We will be launching OSSIX®GRAFT (allograft bone particulate) by the end of the 2016 summer and OSSIX® VOLUMAX (thicker scaffold membrane) shortly afterwards.  Stay tuned!

@Hesira_Med

OSSIX® PLUS is available online HesiraMed.com

June 02, 2016

Education ›  


Is Fibrin an obstacle to bone regeneration?

Hesira Med is dedicated with being well informed with all research being conducted into the bone healing process.  An intriguing article regarding this topic was recently conducted by Vanderbilt University. This article used mice that were deficient in the gene for fibrin production to study healing rates in fractures. To their surprise they found that fibrin was not essential to bone repair, mice deficient in fibrin were still able to repair bone at a normal rate. Furthermore they found that mice who were unable to perform fibrinolysis had impaired vascularization through out the fracture, and difficulty in regenerating bone. This indicates that rather than being essential for bone regeneration, fibrin is an obstacle. While a great deal of research is still needed to verify the validity of these studies, if true, this is an impressive new finding which could change the way we view bone regeneration.

 

@Hesira_Med



OSSIX® PLUS is available online HesiraMed.com

 

May 03, 2016

Education Events ›  


Canadian Academy of Periodontology (CAP)

Hesira Med is a proud supporter of the Canadian Academy of Periodontology (CAP) as they strive to ensure that all Canadians receive an adequate standard of periodontal care. The 2016 CAP meeting is being held this month in Calgary, AB, and will prove to be full of excitement with previews of upcoming products from Hesira Med.  We are dedicated to educating clinicians in the field of regeneration and bone augmentation so that they may consider the appropriate materials to best use on their patients.  We look forward to attending the upcoming CAP meeting and presenting a new game-changing innovative product.  We are very excited about this new product that comes to us from the OSSIX family of products. Hesira Med prides itself our providing superior customer service. 

 

@Hesira_Med



OSSIX® PLUS is available online HesiraMed.com

April 08, 2016

Education ›  


Anti-Depressants Delay Rate of Bone Growth

A new study has identified the use of anti-depressants as a potential factor affecting implant success rates by effecting the rate of bone growth. While patients can be spoken to and reasoned with, someone who needs to be on anti-depressants should not simply stop using them.  Heavy smokers who should stop may promise to cut back but be unable to follow through. Clinicians can manage these risk factors by choosing procedures and products accordingly. OSSIX PLUS is a stable barrier acting to direct bone growth, not just for weeks but for months after placement. It will continue to excel when secondary exposure occurs, when primary exposure is unable to be achieved, and, if bone growth is slowed by the use of anti-depressants. OSSIX PLUS will remain as long as needed before finally ossifying. OSSIX PLUS is strong and reliable as a barrier, so that you may achieve predictable bone growth results.  Consider using OSSIX PLUS today so that you may better manage these high-risk regenerative cases.

 

@Hesira_Med



OSSIX® PLUS is available online HesiraMed.com

March 01, 2016

Education Events ›  


Predictable GBR Results using the OSSIX® PLUS membrane

At the recent AO (Academy of Osseointegration) meeting in San Diego, Dr. Barry Levin, DMD, presented:

Guided Bone Regeneration in Challenging Situations: Predictable Results with the OSSIX® PLUS Membrane, Including Sites with Secondary Closure

Predictability in bone regeneration is critical for clinical success. A membrane capable of calcification over bone grafts provides the maximum regeneration. When membranes are left exposed to the oral environment, rapid degradation can compromise results. The presentation demonstrated intentionally-exposed membranes leading to predictable bone formation, and ideal implant positioning. The unique properties of the OSSIX® PLUS membrane and how it can enhance clinical outcomes in challenging situations was presented.

@Hesira_Med



OSSIX® PLUS is available online HesiraMed.com

November 14, 2015

Education Events ›  


American Academy of Periodontology 101st Annual Meeting

Dr. Rodrigo Neiva presented at the AAP in Orlando, Florida today on Guided Bone Regeneration Techniques for Treatment of Peri-Implant Bone Loss in Cases with Primary and Secondary.  He presented how non soft tissue isolation leads to connective tissue and that soft tissue isolation leads to true bone formation.  Successful bone augmentation with short lasting bone material (allograft) requires a long lasting barrier membrane.  He said that 'the only way to get away with using a short lasting membrane is by using a long lasting bone material'.  He believes that the goal today for GBR is to have better quality bone.  He mentioned that due to the fact that the OSSIX PLUS resorbable collagen membrane is long lasting and highly biocompatible that it can ossify.  He presented studies which included:  Zubery, Nir, Goldlust Ossification of a Collagen Membrane Cross-Linked by Sugar: A Human Case Series J Periodontal - June 2008. 




                                                                                        
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